Cognitive impairment and Osteoporosis are two chronic degenerative diseases in which each of them and in combination can cause significant functional impairment in the elderly. A few of studies have shown that low bone mineraldensity(BMD)is associated with increased risk of cognitive impairment and Alzheimer and vise versa. In this study, we aimed to measure the association between these two diseases in the elderly in Amirkola, Mazandaran ,north of Iran. This cross-sectional study, came from Amirkola Health an Aging Project (AHAP), the BMD was measured by dual-energy X-ray absorptiometry using Lexxos densitometry of the left femoral neck and lumbar spine (L2-4) and the results were expressed based on T-Score. Also, the MMSE standard questionnaire (Mini Mental State Examination) was used to assess cognitive impairment.Data were analyzed using SPSS17statistical software, chisquare test, t-test, Pearson correlation , and after adjusting for several confounding variables in multiple logistic regression models we stimated odds ratio and compared cognitive impairment and normal cognitive statuse groups with normal BMD and low BMD groups; P<0.005 was considered meaningful. In the total number of 1176 persons with the average age of 68.43±7, 839 older people with normal cognitive status, hadBMDof the lumbar spine (0.9±0.18gr/cm2) and 337 older adults had abnormal levels of cognitive status (0.79±0.18gr/cm2) (P = 0.000). For femor results, (0.88±0.15gr/cm2)and(0.77±0.15gr/cm2)were obtained respectively (P= 0.000). Confounding factors in osteoporosis and cognitive impairment were considered in findingsin which there was no difference in the results. It seems that bone mineral density is associated with the cognitive status of older people, and this relationship holds true for both sexes.
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