Objective: The current review aims to compile all the up-to-date and available studies including imperative information concerning the therapeutic protocols and endodontic management available for the diagnosticated acute apical abscess cases. Material and methods: The electronic databases PubMed and Google Scholar were searched in this review using specific inclusion and exclusion criteria. The search was performed in December 2018 and updated in October 2019. Among 6328 studies, thirty-one studies satisfied the eligibility criteria and were included in the review to be analyzed. Results: The thirty-one studies showed the therapeutic Protocols and Endodontic Management of dentoalveolar abscesses in removing infections within the root canal system and their effect in periapical tissue healing. These studies investigated different aspects of an acute apical abscess, including endodontic management, antibiotic therapy, and therapeutic protocols. Conclusion: The compiled data observed that the decision for which treatment should be accomplished changes by patient manifestations when the exceptional acute apical abscess can show local and systemic causes, which can diversify the indicated therapy. At long last, a suitable finding is critical to characterize the patient’s best treatment approach and life support. When it improves the determination of the best treatment approach to manage to be used and avoid medicine aimless use, mainly antibiotics, and maximally decreasing malpractice or potentially superfluous methods.