Background: This study aims to extend the knowledge regarding the psychological component of Ulcerative colitis (UC). Materials and methods: Eight questionnaires were completed and were performed deep psychosocial anamnesis, semi-structured interview, and observation, to reconstitute biography, critical incidents of the environmental conditions of the patient (MC) with ulcerative colitis from 2008. Results: Before the diagnosis he had a year bloody diarrhoea, abdominal pain, and a weight loss of 8 kg, that had greatly affected his work, his family and sexual life. The deviation from the socially encouraged norms regarding the life cycles-such as the successful completion of the studies, career, marriage, becoming a parent, children exceeding the socioeconomic and professional status of the family of origin, etc., perceived as catastrophes, frustrated the patient, and exhausted his energy. Psychological questionnaires showed tendency towards instability at the limit, tendency toward accentuation for emotivity and hyperthymia and was identified as the patient often feels tense. Conclusion: Is necessary a rigorous psychosocial anamnesis to reveal the emotional stresses, to introduce a psychologist, a psychotherapist in evaluating and treating the patients with UC.