Utility of Procalcitonin Test in Appropriate Antibacterial Choice: Retrospective Evaluation | Abstract

International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)


Utility of Procalcitonin Test in Appropriate Antibacterial Choice: Retrospective Evaluation

Author(s):Almutairi Fares G, Alsubayie Noura S, Gramish Jawaher A and Shawaqfeh Mohammad S

Background: Procalcitonin testing (PCT) demonstrates its effectiveness for specifically diagnosing bacterial infections, as it is elevated in bacterial infections but not viral infections. Its clinical usefulness has been shown with antibiotic selection for different infections. Methods: This retrospective observational study aims to evaluate PCT test clinical utility in reducing the use of antibiotics, and the length of hospital stays. The study conducted at a tertiary hospital in Riyadh, Saudi Arabia included a total of 660 patients who were ordered procalcitonin test. Results: Subjects were grouped according to PCT level. All patients with PCT level ≥ 0.1 ng/ml (n=457) are qualified to receive antibiotic treatments. A total of 75.7% were prescribed antibiotics. The length of hospital stay (LOS) in patients who received antibiotics was statistically significantly higher than patients who did not receive any antibiotics (LOS 32.7 vs. 65.1 days, p-value=0.01). However all patients with PCT level <0.1ng/mL (n=203) show no statistically significant difference in the length of stay at hospital among patients who were prescribed an antibiotic or not (p-value=0.64). Only 31% of this group has inappropriately prescribed an antibiotic. Another infection precursor-like WBC count was also evaluated with no significant differences among groups. Conclusion: This study showed that the utilization of PCT guided antibiotic prescribing reduces the length of stay and reduces antibiotic use. PCT guided antibiotic prescribing can be utilized efficiently in hospital settings.

Scope Categories
  • Clinical Research
  • Epidemiology
  • Oncology
  • Biomedicine
  • Dentistry
  • Medical Education
  • Physiotherapy
  • Pulmonology
  • Nephrology
  • Gynaecology
  • Dermatology
  • Dermatoepidemiology
  • Otorhinolaryngology
  • Ophthalmology
  • Sexology
  • Osteology
  • Kinesiology
  • Neuroscience
  • Haematology
  • Psychology
  • Paediatrics
  • Angiology/Vascular Medicine
  • Critical care Medicine
  • Cardiology
  • Endocrinology
  • Gastroenterology
  • Infectious Diseases and Vaccinology
  • Hepatology
  • Geriatric Medicine
  • Bariatrics
  • Pharmacy and Nursing
  • Pharmacognosy and Phytochemistry
  • Radiobiology
  • Pharmacology
  • Toxicology
  • Clinical immunology
  • Clinical and Hospital Pharmacy
  • Cell Biology
  • Genomics and Proteomics
  • Pharmacogenomics
  • Bioinformatics and Biotechnology
  • Google scholar citation report
    Citations : 2979

    International Journal of Medical Research & Health Sciences received 2979 citations as per google scholar report

    International Journal of Medical Research & Health Sciences peer review process verified at publons

    agar io

    wormax io

    Elektronik Sigara
    Elektronik Sigara