Purpose: The aim of this study was to gain an understanding of the problems and difficulties facing new graduate nurses in the transition to the clinical setting, from the perspective of experienced nurses. Methods: Qualitative study was conducted using conventional content analysis method. The participants were 18 experienced nurses in six teaching and governmental hospitals in Iran. Analysis of data highlighted the vulnerability of newly graduated nurses in the clinical setting. This has been revealed by categories including: lack of competency, poor social skills, lack of self-esteem, emotional turmoil, imbalance in demands and resources, inadequate support, and cultural problems. Conclusions: It is essential to review undergraduate curriculums, develop support programs that make up for the existing failures, and eliminate sources of distress in order to protect the personal and professional wellbeing of new graduates and improve retention.