International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Mukesh Kumar
Department of Biochemistry, GR Medical College, Gwalior, Madhya Pradesh, IndiaPublications
-
Research
Association of Secreted Frizzled Related Protein-4 (SFRP-4) and Adiponectin (APN) in the Early Stage Progression of Insulin Resistance in Pre-diabetic Obese Subjects
Author(s): Mukesh Kumar*, Neelima Singh and Ashish Kumar Sharma
Background: Pre-diabetes is a condition characterized by increased plasma glucose levels that fall somewhere between normoglycemia and hyperglycemia. It can be caused by the derangement in the fasting glucose, glucose tolerance, or both. SFRP-4 (Secreted Frizzled-Related Protein-4) is extensively expressed in adipose cells and beta cells of the pancreas, and its levels are elevated many years before diabetes is diagnosed. Adiponectin (a peptide hormone) is secreted by the adipose tissue that was reported to have insulin-sensitizing properties. Aim: To compare the levels of serum SFRP-4 and serum adiponectin in pre-diabetic obese subjects to the levels in control subjects. We also studied the correlation of serum SFRP-4 and serum adiponectin with anthropometric parameters, IGT, fasting blood glucose, and lipid profile. Mate.. Read More»
Select your language of interest to view the total content in your interested language