International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Nordin bin Simbak
Faculty of Medicine, University Sultan Zainal Abidin, Kuala Terengganu, MalaysiaPublications
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Research
Antihypertensive and Antihyperlipidemic Effects of Thymoquinone in L-NAME-Induced Hypertensive Rats
Author(s): Marwan Saad Azzubaidi*, Uday Younis Hussein Abdullah, Nordin bin Simbak, Shazia Jamshed and Hussam Mizher
Thymoquinone (TQ) is gaining increasing considerations in medical research due to its broad spectrum of biological activities against diseases such as neurodegeneration and hypertension. The objective of this study was to evaluate the antihypertensive and lipid-lowering potential of TQ on L-NAME-induced hypertensive rats. Hypertension was induced in 36 Sprague Dawley rats by administration of L-Nitro-Arginine Methyl Ester (L-NAME) in drinking water for 4 weeks. Then rats were divided into 6 groups (n=6): L-NAME–alone, L-NAME+TQ2.5, L-NAME+TQ5, L-NAME+TQ10, L-NAME+captopril, an.. Read More»
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