GET THE APP

Antihypertensive and Antihyperlipidemic Effects of Thymoquinone in L-NAME-Induced Hypertensive Rats | Abstract
Logo

International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)

Abstract

Antihypertensive and Antihyperlipidemic Effects of Thymoquinone in L-NAME-Induced Hypertensive Rats

Author(s):Marwan Saad Azzubaidi*, Uday Younis Hussein Abdullah, Nordin bin Simbak, Shazia Jamshed and Hussam Mizher

Thymoquinone (TQ) is gaining increasing considerations in medical research due to its broad spectrum of biological activities against diseases such as neurodegeneration and hypertension.  The objective of this study was to evaluate the antihypertensive and lipid-lowering potential of TQ on L-NAME-induced hypertensive rats. Hypertension was induced in 36 Sprague Dawley rats by administration of L-Nitro-Arginine Methyl Ester (L-NAME) in drinking water for 4 weeks. Then rats were divided into 6 groups (n=6): L-NAME–alone, L-NAME+TQ2.5, L-NAME+TQ5, L-NAME+TQ10, L-NAME+captopril, and control. Mean Arterial Pressure (MAP) and heart rate was recorded by the non-invasive tail-cuff technique weekly for 28 days. TQ reversed established hypertension in TQ5 and TQ10 groups and prevented further increase in MAP in the TQ2.5 group. Unlike the captopril treated group, TQ antihypertensive activity was associated with an increase in serum aldosterone concentration and ACE activity. TQ treatment at the high dose significantly lowered total cholesterol and LDL levels in comparison with the healthy control group at the end of the 4th week of treatment. This study confirms the antihypertensive action of TQ. Furthermore, it can be concluded that inhibition of ACE did not play a role in the underlying antihypertensive mechanism. However, blocking angiotensin II receptors is a likely mechanism for lowering the MAP.


Archive
Scope Categories
  • Clinical Research
  • Epidemiology
  • Oncology
  • Biomedicine
  • Dentistry
  • Medical Education
  • Physiotherapy
  • Pulmonology
  • Nephrology
  • Gynaecology
  • Dermatology
  • Dermatoepidemiology
  • Otorhinolaryngology
  • Ophthalmology
  • Sexology
  • Osteology
  • Kinesiology
  • Neuroscience
  • Haematology
  • Psychology
  • Paediatrics
  • Angiology/Vascular Medicine
  • Critical care Medicine
  • Cardiology
  • Endocrinology
  • Gastroenterology
  • Infectious Diseases and Vaccinology
  • Hepatology
  • Geriatric Medicine
  • Bariatrics
  • Pharmacy and Nursing
  • Pharmacognosy and Phytochemistry
  • Radiobiology
  • Pharmacology
  • Toxicology
  • Clinical immunology
  • Clinical and Hospital Pharmacy
  • Cell Biology
  • Genomics and Proteomics
  • Pharmacogenomics
  • Bioinformatics and Biotechnology
  • Google scholar citation report
    Citations : 2979

    International Journal of Medical Research & Health Sciences received 2979 citations as per google scholar report

    International Journal of Medical Research & Health Sciences peer review process verified at publons

    paper.io

    agar io

    wowcappadocia.com
    cappadocia-hotels.com
    balloon-rides.net

    wormax io

    Elektronik Sigara
    Elektronik Sigara