International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Santosh K Singh
Department of Biotechnology, ARKA Jain University, Jamshedpur, Jharkhand, IndiaPublications
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Research
Molecular Characterization of Colistin Resistant Klebsiella Pneumoniae ST11 Responsible for Nosocomial Outbreak in Neonatal Intensive Care Unit, India
Author(s): Santosh K Singh*
The dramatic increase of resistance in Klebsiella pneumoniae (K. pneumoniae) due to the misuse of antibiotics poses one of the greatest health threats and is a global health concern. Colistin, a last resort antibiotic is used extensively to treat carbapenem-resistant Klebsiella pneumoniae infections. Present research carried out to analyze the molecular mechanism, clonal types, and outcomes of the infections caused by colistin-resistant K. pneumoniae in neonates during an outbreak in neonate intensive care unit. Twenty-eight cases of colistin-resistant, carbapenem-resistant K. pneumoniae were identified between March and April 2016. Isolates were genotyped using multi-locus sequence typing and the molecular mechanism of colistin resistance was ascertained. All the colistin-resistant K. pneumoniae isolated from neonates during outbreak have insertion.. Read More»
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