International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Sumaiya Al Hajree
Department of Pharmacology, Deccan School of Pharmacy, Hyderabad, IndiaPublications
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Research
Comparison of Once-Daily Triple Therapy versus Conventional Triple Therapy for Patient Compliance and the Eradication of Helicobacter pylori Infection
Author(s): Naila Mohiuddin*, Sumaiya Al Hajree, Ruqiya Fatima, Mohammed Mustaneer Akmal, Syed Ibrahim Hassan, Asif Rasheed and Aleem Ahmed Khan
Aim: To compare the effectiveness of once-daily triple therapy with conventional triple therapy for the eradication of H. pylori. Materials and methods: A prospective comparative study in the gastroenterology unit of a tertiary care hospital was conducted for 6 months. 180 patients with active peptic disease tested positive for rapid urease test or 13C-UBT and concomitantly positive for anti-H. pylori antibodies IgG and IgM were given either once-daily (Tinidazole 1000 mg+Azithromycin 500 mg+Rabeprazole 40 mg) or twice-daily (Amoxicillin 500 mg+Clarithromycin 500 mg+Esomeprazole 40 mg) first-line therapy for ten days. Ten weeks after the completion of therapy rapid urease test and 13C-UBT were repeated. Adherence and adverse events were evaluated using pill count, structured questionnaires, and exit interviews... Read More»
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