Background: Thyroid hormones and lipid profile are among the major determinants of greater body weight and these abnormalities are being influenced in higher Body Mass Index (BMI). The studies concerning the impact of overweight/obesity in the levels of thyroid hormones and lipid profile are not conclusive. Objectives: The study is to examine the correlations of thyroid hormone and lipid profile in different grades of BMI. Materials and Methods: This cross-sectional study was conducted in the Department of Physiology, Regional Institute of Medical Sciences, Imphal, and enrolled 600 subjects (either sex) aged 20-65 years. After getting consent from the subjects without a known history of chronic metabolic disorders and women not under the lactation period, blood samples were collected for the estimation of serum levels of leptin, insulin, thyroid hormones, and lipid profiles. The study population was categorized as non-obese (BMI<25 kg/m2) and obese (BMI ≥ 25 kg/m2). Data were presented as mean and standard deviation by calculating significance using student’s t-test and for correlations, Pearson’s coefficient was used. Significance was p<0.05. Results: In this study, Body Fat percentage (BF%) were increased significantly in obese than non-obese (p<0.01), whereas thyroid hormones (thyroxine (T4), Thyroid Stimulating Hormone (TSH) and lipid profile Total Cholesterol (TC), Triglycerides (TG), High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL) and Very Low-Density Lipoprotein (VLDL) levels were not found significant differences between non-obese and obese groups. BMI had no correlations significantly with thyroid hormones and lipid profile. However, T4 had negative correlations with lipid profile (p<0.05) wherein, TSH levels were found no correlations with lipid profile. Conclusion: Our study found the associations of thyroid hormone and lipid profile without an influence of higher BMI.