Using coping methods can help to dominate on physical, mental, and social relationships, individual contradiction problems, and can be considered as one of effective factors in general and mental health of nurses. The objective of the present research is predicting job stress based on elements of coping styles in nurses. By correlative methodology for this research, 120 female20-45 years old nurses in Tehran city were selected by simple random sampling method based on Cochran formula. The research instrument includes job stress questionnaire and coping style questionnaire of Lazzarus & Folkman; the Pearson correlation coefficient test, and linear regression were used to test hypotheses and generalize the obtained information from tests. Findings showed that participants’ scores were near normal range and Cronbach’s alpha coefficient was 0.58 which indicated scores internal consistency. The obtained results showed that coping elements in 0.05 significant level with f-value of 12.403 significantly predicted job stress. In addition, regression coefficient among support, responsibility, and managerial solution elements was negative and positive with two other relationships including job stress and escape-avoidance. Therefore, it can be concluded that elements of support, responsibility, escape-avoidance, and managerial solution significantly predict nurses’ job stress among coping elements.