Background: Sickle cell disease is an inherited disorder caused by the single point mutation due to the replacement of valine for glutamic acid at the sixth codon of β-chain of globin’s (β6Glu-Val). The sickle cell disease condition with hepatic dysfunction shows abnormal variations in liver function tests including serum aminotransferases enzymes like Serum Glutamic-Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) levels were changed to discuss their significance in sickle cell disease. Objectives: Study of SGOT and SGPT level variation in sickle cell disease. Study of Pearson’s correlation coefficient of Serum Glutamic-Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) in sickle cell disease. Methods: This study was conducted in the Department of Biochemistry, People’s College of Medical Sciences and Research Centre (PCMS & RC), and Centre for Scientific Research and Development Department (CSRD), People’s University, Bhopal. The study protocol and ethical clearance had been approved by Institutional Ethical Committee (Reference number PCMS/OD/2016/2551). The sample size was estimated by the expert statistician, which was 111 for the case sample and controls. These were employed in the research study after the application of the inclusion and exclusion criteria. The liver function enzymes Serum Glutamic-Oxaloacetic Transaminase (SGOT) and Serum glutamic pyruvic transaminase (SGPT) were estimated by Reitman & Frankel’s method and were diagnosed by using the Trans Asia diagnostic kits manufactured by Transasia Bio-Medicals Ltd., B-11, and OpenID Connect (OIDC). Ringanwada, Daman-396210 (India) in collaboration with ERBA diagnostics Mannheim HmbH Mallaustr. 69-73, D-68291, Mannheim/Germany. Results: In the present study, the mean standard deviation of cases vs controls showed a significant difference and it was calculated by using the SPSS latest software version-24. The Mean ± SD cases vs controls of Serum Glutamic-Oxaloacetic Transaminase (SGOT) and Serum glutamic pyruvic transaminase (SGPT) were found in 69.98 ± 69.31, 25.17 ± 5.25 and 65.28 ± 60.07, 22.72 ± 5.47 respectively. The calculated P?0.000 was found to be statistically highly significant. The Pearson’s Correlation showed a positive correlation between Serum Glutamic-Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) enzymes. Conclusions: The transaminases SGOT-SGPT enzymes were significantly increased in sickle cell disease so it could be another clinical biomarker for the diagnosis of sickle cell disease.
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