International Journal of Medical Research & Health Sciences (IJMRHS)
ISSN: 2319-5886 Indexed in: ESCI (Thomson Reuters)
Ali Mohammadi
Zanjan Pharmaceutical Biotechnology Research center, Zanjan University of Medical Sciences, Zanjan, IranPublications
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Research
Induction of Bystander Response in Lung Cancer Cells under Photon Beam Irradiation using Bismuth Sulfide Nanoparticles
Author(s): Leila Nasehi, Hamed Rezaeejam, Hossein Danafar, Parvin Mirzaghavami, Ali Mohammadi, Mahda Delshad and Massoud Vosough*
Background: The use of nanomaterial-based radiosensitizers to improve the therapeutic ratio has gained attraction in radiotherapy. Increased radiotoxicity applied to the tumor region may result in an adverse impact on the unexposed normal cells to the radiation, a phenomenon known as Radiation-Induced Bystander Effect (RIBE). Objective: This study aimed to investigate the effect of Bi2S3@BSA Nanoparticles (NPs) as radiosensitizers on the enhancement of bystander response in non-irradiated cells. Methods: Lung carcinoma epithelial cells were exposed to 6 MV x-ray photons at different doses of 2 and 8 Gy, with and without Bi2S3@BSA NPs. The Irradiated Cells Conditioned Medium (ICCM) was collected and incubated with MCR-5 human fetal lung fibroblasts. Results: This study showed that ICCM collec.. Read More»
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