Background and aim: Exclusive Enteral Nutrition (EEN) is an evidence-based therapy for pediatric Crohn’s Disease (CD). Various clinical studies are conducted to compare the efficacy of polymeric versus elemental formulae in CD. This is the first Indian prospective observational study comparing the therapeutic efficacy of Polymeric Formulae (PF) vs. Semi-Elemental Formulae (SEF) to maintain clinical remission in Pediatric CD. Method: Children with active CD, who commenced on EEN were enrolled. The cohorts were assessed nutritionally and their disease activity was measured using Pediatric Crohn’s disease activity Index. Data were recorded at baseline and after 8 weeks of post EEN. Result: Out of the 38 children recruited, 20 children were treated with SEF and 18 children with PF. 45% children and 50% children were well-nourished in the SEF and PF group respectively. One child relapsed from each of the cohorts within a year. Post therapy, 85% were well-nourished in the SEF group and 77.7% of children were wellnourished in the PF group. In both groups, significant weight gain (p<0.000) was noted at the end of EEN therapy. Conclusion: Polymeric formulae and Semi elemental formulae are effective in inducing clinical remission in active CD with no systemic side effects.